Quantum-Si Incorporated, a proteomics technology company focused on redefining protein analysis through single-molecule detection, has introduced its Version 3 Library Preparation Kit alongside a new suite of data analysis tool enhancements. The launch marks a major step forward in the company’s efforts to enable deeper, more precise protein analysis, particularly in samples where material is scarce or targets are present at very low levels.
When used together with Quantum-Si’s Version 4 Sequencing Kit, released in September 2025, the new library preparation kit significantly improves the analysis of complex biological mixtures and low-abundance biomarkers. Version 3 requires 200 nanograms or less of total protein input—representing a 100-fold improvement over the previous version. Internal validation studies further show that the kit can detect proteins in mixtures with as little as 1–2 nanograms of input, corresponding to under 1% relative abundance within a sample. This level of sensitivity expands the practical use of the platform in applications such as pathway analysis and biomarker discovery, where sample availability is often limited.
Alongside the updated kit, Quantum-Si has released a series of enhancements to its data analysis tools. These updates enable detection of an additional amino acid, methionine, while also improving peptide alignment accuracy and strengthening overall protein inference and interpretability. Together, the software advances are designed to provide researchers with more reliable and comprehensive insights from sequencing data.
Also Read: NVIDIA Unveils Isaac GR00T N1, First Open Humanoid Robot Model
“The Version 3 Library Prep Kit is by far the most sensitive kit the Company has released to date. With the ability to sequence proteins with as little as 1-2 ng of input, our customers will be able to explore low abundance biomarkers and biomarker panels that have been previously inaccessible with our technology,” said Jeff Hawkins, President and Chief Executive Officer of Quantum-Si. “In addition, the new data analysis tools continue to enhance the accuracy and robustness of the data our customers are generating and expands the amino acid coverage to 15 amino acids on path to our goal of demonstrating detection of all 20 amino acids in 2026.”
Together, these advancements underscore Quantum-Si’s ongoing commitment to expanding the sensitivity, accuracy, and analytical reach of next-generation proteomics.